Chemosensitizing effect of Alpinia officinarum rhizome extract in cisplatin-treated rats with hepatocellular carcinoma.
Identifieur interne : 000281 ( Main/Exploration ); précédent : 000280; suivant : 000282Chemosensitizing effect of Alpinia officinarum rhizome extract in cisplatin-treated rats with hepatocellular carcinoma.
Auteurs : Shimaa A. Abass [Égypte] ; Nabil M. Abdel-Hamid [Égypte] ; Tarek K. Abouzed [Égypte] ; Mamdouh Mohammad El-Shishtawy [Égypte]Source :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [ 1950-6007 ] ; 2018.
Descripteurs français
- KwdFr :
- Alpinia (MeSH), Animaux (MeSH), Antinéoplasiques (administration et posologie), Antinéoplasiques (isolement et purification), Antinéoplasiques d'origine végétale (administration et posologie), Antinéoplasiques d'origine végétale (isolement et purification), Carcinome hépatocellulaire (métabolisme), Carcinome hépatocellulaire (traitement médicamenteux), Cisplatine (administration et posologie), Extraits de plantes (administration et posologie), Extraits de plantes (isolement et purification), Mâle (MeSH), Rats (MeSH), Rhizome (MeSH), Résultat thérapeutique (MeSH), Tumeurs du foie (métabolisme), Tumeurs du foie (traitement médicamenteux).
- MESH :
- administration et posologie : Antinéoplasiques, Antinéoplasiques d'origine végétale, Cisplatine, Extraits de plantes.
- isolement et purification : Antinéoplasiques, Antinéoplasiques d'origine végétale, Extraits de plantes.
- métabolisme : Carcinome hépatocellulaire, Tumeurs du foie.
- traitement médicamenteux : Carcinome hépatocellulaire, Tumeurs du foie.
- Alpinia, Animaux, Mâle, Rats, Rhizome, Résultat thérapeutique.
English descriptors
- KwdEn :
- Alpinia (MeSH), Animals (MeSH), Antineoplastic Agents (administration & dosage), Antineoplastic Agents (isolation & purification), Antineoplastic Agents, Phytogenic (administration & dosage), Antineoplastic Agents, Phytogenic (isolation & purification), Carcinoma, Hepatocellular (drug therapy), Carcinoma, Hepatocellular (metabolism), Cisplatin (administration & dosage), Liver Neoplasms (drug therapy), Liver Neoplasms (metabolism), Male (MeSH), Plant Extracts (administration & dosage), Plant Extracts (isolation & purification), Rats (MeSH), Rhizome (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , administration & dosage : Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Cisplatin, Plant Extracts.
- chemical , isolation & purification : Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Plant Extracts.
- drug therapy : Carcinoma, Hepatocellular, Liver Neoplasms.
- metabolism : Carcinoma, Hepatocellular, Liver Neoplasms.
- Alpinia, Animals, Male, Rats, Rhizome, Treatment Outcome.
Abstract
This study was conducted to estimate the preventing and sensitizing efficiency of Alpinia officinarum rhizome extract (AORE) in an experimental model of hepatocellular carcinoma (HCC) +/- cisplatin. HCC was induced by a single intraperitoneal (i.p) dose of diethylnitrosamine (DENA, 200mg/kg). After 14 days, phenobarbitone (PB, 0.05%) was added to drinking water for 14 weeks to promote hepatocarcinogenesis. Cisplatin (CP) was given in a dose of 1.5 mg/kg (i.p), twice a week, alone or with AORE (400 mg/kg daily, orally) for 21 days. AORE was tried as a protective before the induction of HCC for three weeks as well. Results revealed that DENA/PB elevated hepatic indices as ALT and AST and total bilirubin with declining serum total protein. It increased oxidative stress, as hepatic malondialdehyde (MDA) with depressed hepatic reduced glutathione (GSH) contents, superoxide dismutase (SOD) and catalase activities. This was accompanied by an increase in hepatic expression of antioxidant genes (thioredoxin and glutaredoxin). Hepatocarcinogenesis was detected by histopathological changes in liver sections and the elevation of serum alpha-fetoprotein (AFP) level. Treatment with CP partially restored altered hepatic functions and oxidative stress markers. It also showed a partial decrease in the expression of antioxidant genes, improving histopathological changes in the liver and AFP level in serum. The treatment with AORE alone or AORE+CP enhanced hepatic function and oxidative stress markers. It also caused a decrease in the expression of antioxidant genes and improved histopathological changes in liver and serum AFP level. This effect is more potent than the treatment with CP alone. Our study suggested that AORE can be used as a promising natural chemoprevention or a chemosensitizing agent against hepatocarcinogenesis.
DOI: 10.1016/j.biopha.2018.02.128
PubMed: 29524879
Affiliations:
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Abass</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516</wicri:regionArea><wicri:noRegion>33516</wicri:noRegion></affiliation></author><author><name sortKey="Abdel Hamid, Nabil M" sort="Abdel Hamid, Nabil M" uniqKey="Abdel Hamid N" first="Nabil M" last="Abdel-Hamid">Nabil M. Abdel-Hamid</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516</wicri:regionArea><wicri:noRegion>33516</wicri:noRegion></affiliation></author><author><name sortKey="Abouzed, Tarek K" sort="Abouzed, Tarek K" uniqKey="Abouzed T" first="Tarek K" last="Abouzed">Tarek K. Abouzed</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Biochemistry Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516</wicri:regionArea><wicri:noRegion>33516</wicri:noRegion></affiliation></author><author><name sortKey="El Shishtawy, Mamdouh Mohammad" sort="El Shishtawy, Mamdouh Mohammad" uniqKey="El Shishtawy M" first="Mamdouh Mohammad" last="El-Shishtawy">Mamdouh Mohammad El-Shishtawy</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry Department, Faculty of Pharmacy, Mansura University, Mansura, 35516, Egypt. Electronic address: mshisht@mans.edu.eg.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Biochemistry Department, Faculty of Pharmacy, Mansura University, Mansura, 35516</wicri:regionArea><wicri:noRegion>35516</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</title><idno type="eISSN">1950-6007</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alpinia (MeSH)</term><term>Animals (MeSH)</term><term>Antineoplastic Agents (administration & dosage)</term><term>Antineoplastic Agents (isolation & purification)</term><term>Antineoplastic Agents, Phytogenic (administration & dosage)</term><term>Antineoplastic Agents, Phytogenic (isolation & purification)</term><term>Carcinoma, Hepatocellular (drug therapy)</term><term>Carcinoma, Hepatocellular (metabolism)</term><term>Cisplatin (administration & dosage)</term><term>Liver Neoplasms (drug therapy)</term><term>Liver Neoplasms (metabolism)</term><term>Male (MeSH)</term><term>Plant Extracts (administration & dosage)</term><term>Plant Extracts (isolation & purification)</term><term>Rats (MeSH)</term><term>Rhizome (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alpinia (MeSH)</term><term>Animaux (MeSH)</term><term>Antinéoplasiques (administration et posologie)</term><term>Antinéoplasiques (isolement et purification)</term><term>Antinéoplasiques d'origine végétale (administration et posologie)</term><term>Antinéoplasiques d'origine végétale (isolement et purification)</term><term>Carcinome hépatocellulaire (métabolisme)</term><term>Carcinome hépatocellulaire (traitement médicamenteux)</term><term>Cisplatine (administration et posologie)</term><term>Extraits de plantes (administration et posologie)</term><term>Extraits de plantes (isolement et purification)</term><term>Mâle (MeSH)</term><term>Rats (MeSH)</term><term>Rhizome (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Tumeurs du foie (métabolisme)</term><term>Tumeurs du foie (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Agents</term><term>Antineoplastic Agents, Phytogenic</term><term>Cisplatin</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antineoplastic Agents</term><term>Antineoplastic Agents, Phytogenic</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Antinéoplasiques d'origine végétale</term><term>Cisplatine</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antinéoplasiques</term><term>Antinéoplasiques d'origine végétale</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carcinome hépatocellulaire</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome hépatocellulaire</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alpinia</term><term>Animals</term><term>Male</term><term>Rats</term><term>Rhizome</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alpinia</term><term>Animaux</term><term>Mâle</term><term>Rats</term><term>Rhizome</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was conducted to estimate the preventing and sensitizing efficiency of Alpinia officinarum rhizome extract (AORE) in an experimental model of hepatocellular carcinoma (HCC) +/- cisplatin. HCC was induced by a single intraperitoneal (i.p) dose of diethylnitrosamine (DENA, 200mg/kg). After 14 days, phenobarbitone (PB, 0.05%) was added to drinking water for 14 weeks to promote hepatocarcinogenesis. Cisplatin (CP) was given in a dose of 1.5 mg/kg (i.p), twice a week, alone or with AORE (400 mg/kg daily, orally) for 21 days. AORE was tried as a protective before the induction of HCC for three weeks as well. Results revealed that DENA/PB elevated hepatic indices as ALT and AST and total bilirubin with declining serum total protein. It increased oxidative stress, as hepatic malondialdehyde (MDA) with depressed hepatic reduced glutathione (GSH) contents, superoxide dismutase (SOD) and catalase activities. This was accompanied by an increase in hepatic expression of antioxidant genes (thioredoxin and glutaredoxin). Hepatocarcinogenesis was detected by histopathological changes in liver sections and the elevation of serum alpha-fetoprotein (AFP) level. Treatment with CP partially restored altered hepatic functions and oxidative stress markers. It also showed a partial decrease in the expression of antioxidant genes, improving histopathological changes in the liver and AFP level in serum. The treatment with AORE alone or AORE+CP enhanced hepatic function and oxidative stress markers. It also caused a decrease in the expression of antioxidant genes and improved histopathological changes in liver and serum AFP level. This effect is more potent than the treatment with CP alone. Our study suggested that AORE can be used as a promising natural chemoprevention or a chemosensitizing agent against hepatocarcinogenesis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29524879</PMID><DateCompleted><Year>2018</Year><Month>09</Month><Day>24</Day></DateCompleted><DateRevised><Year>2018</Year><Month>09</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1950-6007</ISSN><JournalIssue CitedMedium="Internet"><Volume>101</Volume><PubDate><Year>2018</Year><Month>May</Month></PubDate></JournalIssue><Title>Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</Title><ISOAbbreviation>Biomed Pharmacother</ISOAbbreviation></Journal><ArticleTitle>Chemosensitizing effect of Alpinia officinarum rhizome extract in cisplatin-treated rats with hepatocellular carcinoma.</ArticleTitle><Pagination><MedlinePgn>710-718</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0753-3322(17)35292-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biopha.2018.02.128</ELocationID><Abstract><AbstractText>This study was conducted to estimate the preventing and sensitizing efficiency of Alpinia officinarum rhizome extract (AORE) in an experimental model of hepatocellular carcinoma (HCC) +/- cisplatin. HCC was induced by a single intraperitoneal (i.p) dose of diethylnitrosamine (DENA, 200mg/kg). After 14 days, phenobarbitone (PB, 0.05%) was added to drinking water for 14 weeks to promote hepatocarcinogenesis. Cisplatin (CP) was given in a dose of 1.5 mg/kg (i.p), twice a week, alone or with AORE (400 mg/kg daily, orally) for 21 days. AORE was tried as a protective before the induction of HCC for three weeks as well. Results revealed that DENA/PB elevated hepatic indices as ALT and AST and total bilirubin with declining serum total protein. It increased oxidative stress, as hepatic malondialdehyde (MDA) with depressed hepatic reduced glutathione (GSH) contents, superoxide dismutase (SOD) and catalase activities. This was accompanied by an increase in hepatic expression of antioxidant genes (thioredoxin and glutaredoxin). Hepatocarcinogenesis was detected by histopathological changes in liver sections and the elevation of serum alpha-fetoprotein (AFP) level. Treatment with CP partially restored altered hepatic functions and oxidative stress markers. It also showed a partial decrease in the expression of antioxidant genes, improving histopathological changes in the liver and AFP level in serum. The treatment with AORE alone or AORE+CP enhanced hepatic function and oxidative stress markers. It also caused a decrease in the expression of antioxidant genes and improved histopathological changes in liver and serum AFP level. This effect is more potent than the treatment with CP alone. Our study suggested that AORE can be used as a promising natural chemoprevention or a chemosensitizing agent against hepatocarcinogenesis.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Abass</LastName><ForeName>Shimaa A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdel-Hamid</LastName><ForeName>Nabil M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abouzed</LastName><ForeName>Tarek K</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Biochemistry Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Shishtawy</LastName><ForeName>Mamdouh Mohammad</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Biochemistry Department, Faculty of Pharmacy, Mansura University, Mansura, 35516, Egypt. Electronic address: mshisht@mans.edu.eg.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>03</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Biomed Pharmacother</MedlineTA><NlmUniqueID>8213295</NlmUniqueID><ISSNLinking>0753-3322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000972">Antineoplastic Agents, Phytogenic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q20Q21Q62J</RegistryNumber><NameOfSubstance UI="D002945">Cisplatin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D032429" MajorTopicYN="Y">Alpinia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000972" MajorTopicYN="N">Antineoplastic Agents, Phytogenic</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006528" MajorTopicYN="N">Carcinoma, Hepatocellular</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002945" MajorTopicYN="N">Cisplatin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008113" MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027343" MajorTopicYN="Y">Rhizome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alpinia officinarum</Keyword><Keyword MajorTopicYN="N">Cisplatin</Keyword><Keyword MajorTopicYN="N">Diethylnitrosamine</Keyword><Keyword MajorTopicYN="N">Glutaredoxin</Keyword><Keyword MajorTopicYN="N">Hepatocellular carcinoma</Keyword><Keyword MajorTopicYN="N">Thioredoxin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>02</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>3</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>3</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29524879</ArticleId><ArticleId IdType="pii">S0753-3322(17)35292-7</ArticleId><ArticleId IdType="doi">10.1016/j.biopha.2018.02.128</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Égypte</li></country></list><tree><country name="Égypte"><noRegion><name sortKey="Abass, Shimaa A" sort="Abass, Shimaa A" uniqKey="Abass S" first="Shimaa A" last="Abass">Shimaa A. Abass</name></noRegion><name sortKey="Abdel Hamid, Nabil M" sort="Abdel Hamid, Nabil M" uniqKey="Abdel Hamid N" first="Nabil M" last="Abdel-Hamid">Nabil M. Abdel-Hamid</name><name sortKey="Abouzed, Tarek K" sort="Abouzed, Tarek K" uniqKey="Abouzed T" first="Tarek K" last="Abouzed">Tarek K. Abouzed</name><name sortKey="El Shishtawy, Mamdouh Mohammad" sort="El Shishtawy, Mamdouh Mohammad" uniqKey="El Shishtawy M" first="Mamdouh Mohammad" last="El-Shishtawy">Mamdouh Mohammad El-Shishtawy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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